Sequential bypassing agents during major orthopedic surgery: a new approach to hemostasis.
نویسندگان
چکیده
Sequential bypassing agents may be a safe and effective treatment during major orthopedic surgery in hemophilia patients with inhibitors.
منابع مشابه
The efficacy of bypassing agents in surgery of hemophilia patients with inhibitors
BACKGROUND Inhibitory antibodies to factor VIII (FVIII) or IX (FIX) are important issues when managing patients with hemophilia A or B. Advances in bypassing agents such as recombinant activated FVII (rFVIIa) and activated prothrombin complex concentrates (APCC) have enabled the aggressive management of hemophilia with inhibitors during emergency or elective surgery. This study provides an upda...
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Abstract Background: Hemostasis has turned into one of the major concerns in surgery and anesthesia. Anesthesiologists are always pursuing new methods and medications to avoid allogenic and autologous blood transfusion. The present study aimed at examining the effects of tranexamic acid on the reduction of hemorrhage and the need for transfusion. Methods: A sequential controlled clinical tr...
متن کاملSurgery in patients with congenital factor VII deficiency: A single center experience
BACKGROUND Congenital factor VII (FVII) deficiency is a rare hemorrhagic disorder that can cause excessive bleeding during and after surgery in affected patients. The recombinant form of activated factor VII (rFVIIa, NovoSeven® from Novo Nordisk, Bagsvaerd, Denmark), which was developed as a second-generation bypassing agent, has recently been used in the management of bleeding for patients wit...
متن کاملProspective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgery.
Clinical response to bypassing agents (BPAs) may vary between patients. Surgery is a particular situation, requiring effective hemostasis during the procedure and for several days postoperatively to obtain satisfactory wound healing. However, the optimal dose of BPA in different surgical situations has not been clearly established. We report here a prospective assessment of thrombin generation ...
متن کاملThe effect of ulinastatin on hemostasis in major orthopedic surgery
BACKGROUND Ulinastatin, a urinary trypsin inhibitor, is widely used to treat acute systemic inflammatory disorders. However, the effects of ulinastatin, especially on the potential for hemostasis, have not been fully elucidated. This study examined whether ulinastatin had any beneficial effects on blood loss and blood transfusion requirements in patients undergoing major orthopedic surgery. M...
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ورودعنوان ژورنال:
- Blood advances
دوره 1 17 شماره
صفحات -
تاریخ انتشار 2017